We welcome applications to join our group, especially from young scientists who bring novel expertise or points of view that can be applied to our overall aims.
Our lab (consisting of 10-15 scientists) is located at the Francis Crick Institute Mill Hill Laboratory in North London (UK). We will relocate to the main Crick site (near St. Pancras station, in central London) upon completion of construction in March 2016.
We are generally interested in the signalling activities that control patterning, growth and apoptosis in epithelia. Here are some of the questions we investigate:
- How do signalling molecules organise tissues?
- How are malfunctioning cells recognised and eliminated within epithelia?
- How are pro-growth signals integrated to ensure ‘just-right’ tissue size?
We are particularly interested in the contribution of signals mediated by Wnt/β-catenin, JNK, Hedgehog and Decapentaplegic in these processes.
Our animal model of choice is the fruit fly Drosophila. We also make use of cells in culture when appropriate. Although our research is not applied, we hope that it will help identify molecules and processes that are relevant to human disease (e.g. cancer). In one project, we will use mice, as a first step to investigate such relevance. Our general approach involves merging the power of genome engineering with a variety of techniques borrowed from cell biology, biochemistry, chemistry and physics.
The Vincent lab is mostly funded by the UK Medical Research Council (MRC) and the European Research Council (ERC). We occasionally receive funding from the Wellcome Trust, the European Molecular Biology Organisation (EMBO), the Japan Society for the Promotion of Science (JSPS), and the Swiss National Science Foundation (SNF).
KEYWORDS: wingless, wnt, apoptosis, Crick, NIMR, JP Vincent, Jean-Paul Vincent, Vincent lab, morphogen, Drosophila, patterning, signalling.